Welcome to ChemTaurus GmbH

ChemTaurus GmbH, originally a spin-off from the University of Bremen, is a privately owned German Chemical Company. Our rapidly growing company was founded in 2008 by a group of chemists with many years of experience in both applied and basic research in organic, organofluorine, and organophosphorus chemistry. Our work has resulted in numerous patent applications and publications with Bayer AG, Aventis AG, Degussa AG, Merck KGaA and LG International Corporation.

A series of robust, easily recyclable and highly efficient catalysts have been developed. These unique compounds represent a new family of salts of delocalized lipophilic cations with remarkably high potential for solid-liquid phase-transfer halide exchange. Novel effective fluorinating reagents based on α,α-difluoroamines have been developed and evaluated.

We provide new products and intermediates for materials, pharmaceutical, and crop protection industries, including custom-made fluorinated synthons, building blocks and catalysts.

ChemTaurus makes numerous trifluoromethoxylating and pentafluoro-ethoxylating reagents. Trifluoromethoxylation of alcohols andhydroxy acid esters provides easy technological access to functionalized CF₃O-aliphatic substrates. Furthermore, we develop novel aliphatic building blocks bearing lipophilic, yet metabolically stable trifluoromethoxy and trifluoromethylthio substituents for incorporation into small molecules in life science-oriented research. Useful intermediates for a variety of bioactive compounds including therapeutic agents is also our specialty. Among ChemTaurus-developed tools for drug design are fluorine-containing amines and amino acids for the construction of novel, selectively fluorinated peptide and protein structures.

We are experts in making various functionalized trifluoromethylthio and trifluoromethyl pyrazines, pyridazines and bis(trifluoromethyl)-pyridines for medicinal chemistry and crop protection needs.

We have also developed a general route to functionalizedpentakis(trifluoromethyl)benzene derivatives, including C₆(CF₃)₅OH, C₆(CF₃)₅Cl, C₆(CF₃)₅NH₂, and C₆(CF₃)₅COOH. These compounds, available from ChemTaurus, are unique, highly promising building blocks for the synthesis of novel stable carbenes, radical species, superacids, weakly coordinating anions, and other materials for both applied and basic research.

Our Key Competences, Technologies, and Products:

Fluorinated functionalized aromatic compounds bearing F, CF₃, C₂F₅, OCH₂CF₃, OCF₃, and OCH₂CH₂OCF₃ substituents; Fluorinated aromatic amino acids; and Fluorine-containing functionalized pyrazines andpyridazines containing F, CF₃, C₂F₅, OCH₂CF₃, OCF₃, OCH₂CH₂OCF₃ and NH₂CH₂CH₂OCF₃ groups.

A New Direct Trifluoromethoxylation and Pentafluoroethoxylation of functionalized Aliphatic Substrates

Fluorine-containing alcohols bearing CF₃, CF₃O and C₂F₅O groups;

Fluorinated alkyl amines with CF₃, CF₃O, C₂F₅O and C₂F₅S substituents;

Proline and pyrrolidine derivatives bearing CF₃O and C₂F₅O functionalities; and

Trifluoromethoxylated and trifluoromethylthiolated alkyl bromides.

Novel Organic Solvent-Soluble TetraalkylammoniumTrifluoromethanolates and Pentarluoroethanolates

[Et₄N]+ [CF₃O]-, [Pr₄N+] [CF₃O]-, [Bu₄N]+ [CF₃O]- and [Me₄N]+ [C₂F₅O]-.

Functionalized pyridines, pyrazines, pyridazines

Fluorine-containing functionalized pyridine, pyrazine, and pyridazineheterocycles bearing CF₃, C₂F₅, CF₃S and C₂F₅S groups;

Benzofuran-2-carboxylic acid and benzofuran-2-carboxylic acid alkyl esters with F, CF₃ and C₂F₅ substituents.

Effective Application of FAR and similar reagents

Fluorination with FAR-reagents, SF₄, DAST, phenylsulfur trifluoride and tetrabutylammonium dihydrogen trifluoride. Useful patent-free effective fluorinating reagents comprising α,α-difluoroamines.

These reagents rapidly fluorinate a broad variety of alcohols, aldehydes, acids, and ketones under mild conditions to yield the corresponding fluorinated compounds with high efficiency and selectivity.

Capacities and production: Handling and storage on a 100 g scale

Fluoromethylation, difluoromethylation, and trifluoromethylation: Perfluoroalkylating Ruppert-Prakash reagents and scaleup (100 g - 1 kg) synthesis and use of ethyl difluoro(trimethylsilyl) acetate.

Robust PT catalysts for fluorination and use in numerous organic reactions requiring extremely harsh conditions: Aromatic andheteroaromatic derivatives - Solid-liquid phase transfer Halex fluorination.

Polyfluoroalkylation: mono- and polytrifluoromethyl derivatives as promising building blocks for the design of novel stable carbenes, radical species, superacids, and weakly coordinating anions.

Trifluoromethyl Phosphorus (III) and (V) compounds

Synthesis and Biomedical Application of novel Fluorinated Phosphonates

In addition to the products listed in our catalog, we offer contract manufacturing and custom synthesis on a gram to kilogram scale. Our PhD chemists are available for FTE research or contract synthesis projects.

Please contact us for more information.